Endocrine Abstracts

Peripheral insulin resistance is a major defect associated with glucose intolerance and type two diabetes. Yet the mechanism(s) responsible for this defect remain to be determined. Inositol pyrophosphate (IP7) is formed via the enzyme IP6K1 from IP6. The inhibition of Akt, and the potential decrease in insulin signalling, through the binding of IP7 to the Akt PH domain represents an exciting research area.Firstly, we will characterise this mechanism in h...